First verify that the Zscaler client is running and connected. You can do this by clicking on the zscaler icon in the windows system tray or the mac menu and selecting open zscaler. Verify that the service status shows ON

Once you verify you are connected, verify that you are using the fully qualified domain name(fqdn) of the resource you are trying to access. This means that you will need to use the full name of the resource (example: https://resource.uwyo.edu) when accessing on campus resources.
Some secure resources require your machine to be patched and up to date. Make sure you are running a supported operating system and up to date on security patches.
If you are still unable to connect contact the help desk